Engineering composite programmable therapeutic agents to advance medicine.

What does programmable mean?

Computationally designed single strands of DNA self-assemble into programmed nanoscale structures of choice. These structures are stable, non-toxic, non-immunogenic, and non-inflammatory. The sequences of the DNA molecules used to build them are fully user programmable and may include non-coding elements and elements that encode for user-defined genetic features. The structures are fully chemically addressable by covalently conjugating other molecules to selected DNA strands.

Similarly, we use computational design to develop custom peptide and protein binders for realizing cellular targeting and therapeutic activities.